S-10 is 5 x4.5 whereas the Astro is 5 x5 bolt patterns are different. The only thing different from the front axle on the Astro to the S-10 is the lockout itself. Which as Rod said only frees the wheels in the sense that the hubs are not powered but freewheeling when locked out. The transfer is still sending power to the front axle, just not the front hubs. Very little if any gas mileage saved. People don't buy Astro/Safari vans for gas mileage, they buy them because they are great vans overall.