2000 Astro AWD drains the battery while nothing is on. Is this the security system? Is it the FOB circuitry monitoring button press?
While disconnecting the positive battery terminal, sparks can be seen. When the van sits parked for a few months it has to be jump started.
One could assume that while the ignition is off and the door is opened to deactivate accessory power that battery power would not be draining.